Reversing Arterial Calcification
Elastrin Therapeutics has the first therapy that dissolves calcified deposits to improve vascular function by focusing on a unique target
Reversing Arterial Calcification
Elastrin Therapeutics has the first therapy that dissolves calcified deposits to improve vascular function by focusing on a unique target
Reversing Arterial Calcification
Elastrin Therapeutics has the first therapy that dissolves calcified deposits to improve vascular function by focusing on a unique target
The Mission of Elastrin Therapeutics is to eliminate arterial calcification as a threat to health and longevity. Our goal is to improve patient outcomes by safely increasing drug effectiveness and reducing the risk of off-targeting.
Calcification is a hard mix of minerals and salts, affecting 1 in 4 people globally [1]. It builds up in arteries, raising the risk of problems like heart attack, heart valve failure, stroke, and stent failure [2].
The image at right shows where calcification often happens. It is especially serious in Peripheral Artery Disease (PAD), where blood flow to the legs is blocked. PAD affects more than 200 million people around the world [3].
[1] Chen et al. (2022). Frontiers in Cardiovascular Medicine, 9, 911871
[2] Shanahan, C. M. et al, Nature Reviews Cardiology, 19(11), 701–723
[3] Fowkes et al The Lancet, 382(9901), 1329-1340
The Mission of Elastrin Therapeutics is to eliminate arterial calcification as a threat to health and longevity. Our goal is to improve patient outcomes by safely increasing drug effectiveness and reducing the risk of off-targeting.
Calcification is a hard mix of minerals and salts, affecting 1 in 4 people globally [1]. It builds up in arteries, raising the risk of problems like heart attack, heart valve failure, stroke, and stent failure [2].
The image at right shows where calcification often happens. It is especially serious in Peripheral Artery Disease (PAD), where blood flow to the legs is blocked. PAD affects more than 200 million people around the world [3].
[1] Chen et al. (2022). Frontiers in Cardiovascular Medicine, 9, 911871
[2] Shanahan, C. M. et al, Nature Reviews Cardiology, 19(11), 701–723
[3] Fowkes et al The Lancet, 382(9901), 1329-1340
The Mission of Elastrin Therapeutics is to eliminate arterial calcification as a threat to health and longevity. Our goal is to improve patient outcomes by safely increasing drug effectiveness and reducing the risk of off-targeting.
Calcification is a hard mix of minerals and salts, affecting 1 in 4 people globally [1]. It builds up in arteries, raising the risk of problems like heart attack, heart valve failure, stroke, and stent failure [2].
The image at right shows where calcification often happens. It is especially serious in Peripheral Artery Disease (PAD), where blood flow to the legs is blocked. PAD affects more than 200 million people around the world [3].
[1] Chen et al. (2022). Frontiers in Cardiovascular Medicine, 9, 911871
[2] Shanahan, C. M. et al, Nature Reviews Cardiology, 19(11), 701–723
[3] Fowkes et al The Lancet, 382(9901), 1329-1340
Elastin is a stretchy fiber in arteries that helps them stay flexible. But as we age, elastin breaks down. When this happens, calcification often builds up. Arterial calcification is almost always found along with degraded elastin [4].
Elastrin Therapeutics' technology is the only one proven to remove calcification from arteries without invasive surgery. It does this by delivering drugs to damaged elastin where calcification occurs. This unique approach improves effectiveness and safety. Elastrin's initial focus is calcification that threatens patients who have Peripheral Artery Disease.
Our therapy can be delivered systemically or locally, with or without devices and is adaptable to multiple cardiovascular conditions.
[4] Maurice et al., Trends Cardiovasc Med. 2013 Aug;23(6):211-21. doi: 10.1016/j.tcm.2012.12.004.
Elastin is a stretchy fiber in arteries that helps them stay flexible. But as we age, elastin breaks down. When this happens, calcification often builds up. Arterial calcification is almost always found along with degraded elastin [4].
Elastrin Therapeutics' technology is the only one proven to remove calcification from arteries without invasive surgery. It does this by delivering drugs to damaged elastin where calcification occurs. This unique approach improves effectiveness and safety. Elastrin's initial focus is calcification that threatens patients who have Peripheral Artery Disease.
Our therapy can be delivered systemically or locally, with or without devices, and is adaptable to multiple cardiovascular conditions.
[4] Maurice et al., Trends Cardiovasc Med. 2013 Aug;23(6):211-21. doi: 10.1016/j.tcm.2012.12.004.
Elastin is a stretchy fiber in arteries that helps them stay flexible. But as we age, elastin breaks down. When this happens, calcification often builds up. Arterial calcification is almost always found along with degraded elastin [4].
Elastrin Therapeutics' technology is the only one proven to remove calcification from arteries without invasive surgery. It does this by delivering drugs to damaged elastin where calcification occurs. This unique approach improves effectiveness and safety. Elastrin's initial focus is calcification that threatens patients who have Peripheral Artery Disease.
Our therapy can be delivered systemically or locally, with or without devices, and is adaptable to multiple cardiovascular conditions.
[4] Maurice et al., Trends Cardiovasc Med. 2013 Aug;23(6):211-21. doi: 10.1016/j.tcm.2012.12.004.
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© 2025 by Elastrin Therapeutics
© 2025 by Elastrin Therapeutics
© 2025 by Elastrin Therapeutics